Anterior pituitary cells defective in the cell-autonomous factor, df, undergo cell lineage specification but not expansion.

@article{Gage1996AnteriorPC,
  title={Anterior pituitary cells defective in the cell-autonomous factor, df, undergo cell lineage specification but not expansion.},
  author={Philip J. Gage and M. L. Roller and Thomas Saunders and Lori M. Scarlett and Sally A Camper},
  journal={Development},
  year={1996},
  volume={122 1},
  pages={151-60}
}
The Ames dwarf mouse transmits a recessive mutation (df) resulting in a profound anterior pituitary hypocellularity due to a general lack of thyrotropes, somatotropes and lactotropes. These cell types are also dependent on the pituitary-specific transcription factor, Pit-1. We present evidence that expression of Pit-1 and limited commitment to these cells lineages occurs in df/df pituitaries. Thus, the crucial role of df may be in lineage-specific proliferation, rather than cytodifferentiation… CONTINUE READING