Anterior hypothalamic norepinephrine, atrial natriuretic peptide, and hypertension.

  title={Anterior hypothalamic norepinephrine, atrial natriuretic peptide, and hypertension.},
  author={Suzanne Oparil and Yunjia Chen and Ning Peng and J. Michael Wyss},
  journal={Frontiers in neuroendocrinology},
  volume={17 2},
Our laboratory has characterized a model of salt sensitive hypertension, the salt sensitive spontaneously hypertensive rat (SHR-S), in which dietary NaCl supplementation increases blood pressure by reducing norepinephrine release by nerve terminals in the anterior hypothalamic area (AHA), thus reducing activation of sympathoinhibitory neurons in the AHA. This, in turn, results in increased sympathetic outflow and higher blood pressure in the SHR. Two mechanisms have been shown to contribute to… CONTINUE READING


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