Anterior definitive endoderm from ESCs reveals a role for FGF signaling.

  title={Anterior definitive endoderm from ESCs reveals a role for FGF signaling.},
  author={Gillian M. Morrison and Ifigenia Oikonomopoulou and Rosa Portero Migueles and Shamit Soneji and Alessandra Livigni and Tariq Enver and Joshua M Brickman},
  journal={Cell stem cell},
  volume={3 4},
The use of embryonic stem cell (ESC) differentiation to generate functional hepatic or pancreatic progenitors and as a tool for developmental biology is limited by an inability to isolate in vitro equivalents of regionally specified anterior definitive endoderm (ADE). To address this, we devised a strategy using a fluorescent reporter gene under the transcriptional control of the anterior endoderm marker Hex alongside the definitive mesendoderm marker Cxcr4. Isolation of Hex(+)Cxcr4… CONTINUE READING


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Signaling pathways during maintenance and definitive endoderm differentiation of embryonic stem cells.

The International journal of developmental biology • 2013
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