Anterior boundaries of Hox gene expression in mesoderm-derived structures correlate with the linear gene order along the chromosome.

@article{Dressler1989AnteriorBO,
  title={Anterior boundaries of Hox gene expression in mesoderm-derived structures correlate with the linear gene order along the chromosome.},
  author={Gregory R. Dressler and Peter Gruss},
  journal={Differentiation; research in biological diversity},
  year={1989},
  volume={41 3},
  pages={
          193-201
        }
}
  • G. Dressler, P. Gruss
  • Published 1 September 1989
  • Biology
  • Differentiation; research in biological diversity
The developmental expression patterns of four genes, Hox 1.1, Hox 1.2, Hox 1.3 and Hox 3.1, were examined by in situ hybridization to serial embryonic sections. The three genes of the Hox 1 cluster, used in this study, map to adjacent positions along chromosome 6, whereas the Hox 3.1 gene maps to the Hox 3 cluster on chromosome 15. The anterior expression limits in segmented mesoderm varied among the four genes examined. Interestingly, a linear correlation exists between the position of the… 
View on PubMed
pure.mpg.de
82 Citations
Highly Influential Citations
1
Background Citations
13
Methods Citations
6
Results Citations
2

Figures from this paper

82 Citations

Citation Type

Citation Type

Activation of Hox gene expression by Hoxa-5.
  • C. Lobe
  • Biology
    DNA and cell biology
  • 1995
TLDR
There was an 8-hr delay between the peak of expression from the Hox vector and the endogenous Hox gene response, suggesting that Hox proteins activate other Hox genes indirectly or require additional factors which, in F9 cells, they also induce.
Primary structure and embryonic expression pattern of the mouse Hox-4.3 homeobox gene.
TLDR
Hox-4.3 has a primary structure characteristic of a Hox gene but, in addition, contains several monotonic stretches of amino acids, one of the 'paired'-like type, suggesting that 'cluster specificity' could be a feature of the HOX network.
Separate elements cause lineage restriction and specify boundaries of Hox-1.1 expression.
TLDR
Correct regulation by Hox-1.1 sequences in transgenic mice is shown and the elements responsible for different levels of control are identified and shown to be crucial for the restriction of expression.
Structure and expression pattern of the murine Hox-3.2 gene.
The murine homeobox-containing gene Hox-3.2 is the most 5' member of the Hox-3 complex on chromosome 15 isolated to date. Conceptual translation of the longest ORF gives a protein of 260 amino acids…
Expression of the murine homeobox-containing gene Hox-2.3 suggests multiple time-dependent and tissue-specific roles during development.
This study reports the expression pattern of the murine homeobox-containing gene Hox-2.3 during development. Using in situ hybridization, we first detect Hox-2.3 transcripts in the allantois…
Hox-2.3 upstream sequences mediate lacZ expression in intermediate mesoderm derivatives of transgenic mice.
TLDR
The results document the involvement of distinct regulatory elements in Hox gene expression in subsets of cells with distinct developmental fate, situated at similar positions along the anteroposterior axis of the embryo.
A conserved enhancer of the human and murine Hoxa-7 gene specifies the anterior boundary of expression during embryonal development.
TLDR
A minimal enhancer element specifying the anterior boundary of Hox gene expression in early and late phases of development was defined and designated as Hoxa-7 enhancer.
Proximal cis-acting elements cooperate to set Hoxb-7 (Hox-2.3) expression boundaries in transgenic mice.
TLDR
The identification of cis-acting elements controlling the expression of Hoxb-7 (Hox-2.3) is reported here on, showing that elements driving A-P restricted gene expression are located within the 3.5 kb proximal upstream sequences of the Hox b-7 gene.
Disruption of the Hox-1.6 homeobox gene results in defects in a region corresponding to its rostral domain of expression
Position-specific activity of the Hox1.1 promoter in transgenic mice.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 62 REFERENCES
Primary structure and developmental expression pattern of Hox 3.1, a member of the murine Hox 3 homeobox gene cluster.
TLDR
The data support the hypothesis that the Hox 3.1 gene specifies positional information during murine embryogenesis, as deduced from cDNA sequences, and the expression of Hox3.1 mRNA during embryogenesis.
Spatially restricted patterns of expression of the homeobox-containing gene Hox 2.1. during mouse embryogenesis.
TLDR
The data are consistent with these genes having regulatory roles in anteroposterior positional specification in the neuroectoderm and mesoderm, and suggest that Hox 2.1 may also have functions during organogenesis.
Expression of the murine homeo box gene Hox 1.5 during embryogenesis.
Specific expression of the Hox 1.3 homeo box gene in murine embryonic structures originating from or induced by the mesoderm.
TLDR
A role of Hox 1.3 gene in the generation of tissues derived from or induced by the embryonal mesoderm is suggested, as well as in some ectoderm‐derived tissues.
The murine and Drosophila homeobox gene complexes have common features of organization and expression
Pattern of transcription of the homeo gene Hox-3.1 in the mouse embryo.
TLDR
The early transcription pattern appears to be compatible with a regionalizing role for the Hox-3.1 gene, and is localized most intensely in the neural tube region lying above the heart.
Developmental and spatial patterns of expression of the mouse homeobox gene, Hox 2.1.
TLDR
Comparison of the temporal patterns of gene expression during development and in the adult suggests that Hox 2.1 is regulated independently in different tissues.
Mouse homeobox gene transcripts occupy different but overlapping domains in embryonic germ layers and organs: a comparison of Hox-3.1 and Hox-1.5.
TLDR
Two different mechanisms are considered by which positional information might first be generated within the germ layers, which are different, although overlapping, along the anteroposterior axis of the embryo.
Characterization of a murine homeo box gene, Hox-2.6, related to the Drosophila Deformed gene.
TLDR
It is suggested that Hox-2.6 forms part of a vertebrate 'Dfd-like' family, and expression in both mesoderm and ectoderm are spatially restricted and may reflect a role for the gene in the response to or establishment of positional cues in the embryo.
Expression of homeobox gene Hox 1.1 during mouse embryogenesis.
TLDR
The results suggest that homeobox genes probably do not play an exclusive role in segmentation in vertebrates, but are consistent with a role in the assignment of positional identity along the axis of the embryo.
...
1
2
3
4
5
...