Anterior-Posterior Guidance of Commissural Axons by Wnt-Frizzled Signaling

@article{Lyuksyutova2003AnteriorPosteriorGO,
  title={Anterior-Posterior Guidance of Commissural Axons by Wnt-Frizzled Signaling},
  author={A. Lyuksyutova and Chin-Chun Lu and Nancy Milanesio and Leslie A. King and N. Guo and Y. Wang and J. Nathans and M. Tessier‐Lavigne and Y. Zou},
  journal={Science},
  year={2003},
  volume={302},
  pages={1984 - 1988}
}
Commissural neurons in the mammalian dorsal spinal cord send axons ventrally toward the floor plate, where they cross the midline and turn anteriorly toward the brain; a gradient of chemoattractant(s) inside the spinal cord controls this turning. In rodents, several Wnt proteins stimulate the extension of commissural axons after midline crossing (postcrossing). We found that Wnt4 messenger RNA is expressed in a decreasing anterior-to-posterior gradient in the floor plate, and that a directed… Expand
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