Antenatal hypoxia induces epigenetic repression of glucocorticoid receptor and promotes ischemic-sensitive phenotype in the developing heart.

Abstract

Large studies in humans and animals have demonstrated a clear association of an adverse intrauterine environment with an increased risk of cardiovascular disease later in life. Yet mechanisms remain largely elusive. The present study tested the hypothesis that gestational hypoxia leads to promoter hypermethylation and epigenetic repression of the… (More)
DOI: 10.1016/j.yjmcc.2016.01.003

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Cite this paper

@article{Xiong2016AntenatalHI, title={Antenatal hypoxia induces epigenetic repression of glucocorticoid receptor and promotes ischemic-sensitive phenotype in the developing heart.}, author={Fuxia Xiong and Thant Nyi Lin and Minwoo Andrew Song and Qingyi Ma and Shannalee R. Martinez and Juanxiu Lv and Eugenia MataGreenwood and Daliao Xiao and Zhice Xu and Lubo Zhang}, journal={Journal of molecular and cellular cardiology}, year={2016}, volume={91}, pages={160-71} }