Antenatal bacterial endotoxin sensitizes the immature rat brain to postnatal excitotoxic injury.

@article{Rousset2008AntenatalBE,
  title={Antenatal bacterial endotoxin sensitizes the immature rat brain to postnatal excitotoxic injury.},
  author={Catherine I. Rousset and Jinane Kassem and Paul Olivier and Sylvie Chalon and Pierre Gressens and Elie Saliba},
  journal={Journal of neuropathology and experimental neurology},
  year={2008},
  volume={67 10},
  pages={994-1000}
}
Intracerebral injection of ibotenate in newborn rodents produces brain damage that mimics that of infants with cerebral palsy. Because maternal infection may contribute to brain injury in preterm infants, we investigated brain damage after maternal inflammation and postnatal ibotenate treatment in a rat model of cerebral palsy. Pregnant rats were injected intraperitoneally with lipopolysaccharide at Days 19 and 20 of gestation. Neonates were given intracerebral injections of ibotenate at… CONTINUE READING

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