Antenatal Dexamethasone: Effect on Ovine Placental 11β-Hydroxysteroid Dehydrogenase Type 2 Expression and Fetal Growth

Abstract

Antenatal glucocorticoids are routinely given to women at risk for preterm delivery. The fetus is protected from excessive glucocorticoids by the placental enzyme 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD-2), which catalyzes the conversion of cortisol to its biologically inactive metabolite, cortisone. We examined the effects of antenatal… (More)
DOI: 10.1203/00006450-200211000-00016

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