• Corpus ID: 14107861

Antenatal Corticosteroids to Reduce Neonatal Morbidity and Mortality

@inproceedings{Hospital2010AntenatalCT,
  title={Antenatal Corticosteroids to Reduce Neonatal Morbidity and Mortality},
  author={King Edward Memorial Hospital},
  year={2010}
}
In 1972 a study demonstrated that a single course of antenatal corticosteroids treatment may enhance fetal maturation before preterm birth and decrease the rate of respiratory distress syndrome, intraventricular haemorrhage and neonatal death. This treatment results in less neonatal mortality, fewer common neurological and abdominal complications such as cerebroventricular haemorrhage and necrotising enterocolitis. There does not appear to be any negative effects from the corticosteroid for the… 
Neonatal outcomes after oral administration of antenatal corticosteroid: A case report
Respiratory Morbidity in Neonates at or Near-Term in Relation to Mode of Delivery - A Retrospective Observational Study
Introduction: Antenatal corticosteroids are recommended by Royal College of Obstetrics and Gynaecology for caesarean section planned before thirty-eight plus six weeks gestation. However, these
Maternal, fetal, and neonatal outcomes associated with long‐term use of corticosteroids during pregnancy
TLDR
The question as to whether the standard course of antenatal corticosteroids is necessary if preterm delivery is anticipated is discussed and the maternal, fetal and neonatal effects in pregnant women using chronic Corticosteroid are reviewed.
Impact of antenatal corticosteroids on frequency and mortality due to respiratory distress syndrome in preterm neonates.
TLDR
Frequency of RDS and mortality due to this disease in group of infants treated with antenatal steroid is far less than the group of preterm new-borns delivered without this therapy.
The neonatal outcomes of Dexamethasone administration before scheduled cesarean delivery at term: a randomized clinical trial
TLDR
Improvements in surgical techniques and facilities for control of anticipated postoperative pain and complications like hemorrhage, infection, and thromboembolism increased the safety and acceptability of the procedure by both obstetricians and pregnant women.
Respiratory distress syndrome of the newborn
TLDR
The incidence and severity of NRDS is inversely related to gestational age and birth weight, and incidence decreases with prolonged rupture of membranes, chronic pregnancy associated hypertension and antenatal corticosteroid prophylaxis.
Reducing neonatal mortality and respiratory distress syndrome associated with preterm birth: a scoping review on the impact of antenatal corticosteroids in low- and middle-income countries
TLDR
Most of the studies in low- and middle-income countries showed that use of antenatal corticosteroids in hospitals with high levels of neonatal care was associated with lower rates of Neonatal mortality and respiratory distress syndrome, however, the findings are inconclusive.
Extreme prematurity and perinatal management
TLDR
Perinatal management of pregnant women delivering at the threshold of viability should be preceded by the best advice from a multidisciplinary neonatal and obstetric team to fully inform parents and achieve a consensus on the optimal care for the mother and neonate.
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References

SHOWING 1-10 OF 59 REFERENCES
REPEATED COURSES OF ANTENATAL CORTICOSTEROIDS
Antenatal Corticosteroids After Preterm Premature Rupture of Membranes
TLDR
It is concluded that the cumulative level I evidence indicates a definite beneficial effect of corticosteroids in conditions of PPROM.
Antenatal corticosteroid therapy in premature infants
TLDR
Antenatal betamethasone treatment reduces perinatal morbidity and mortality after 28 weeks’ gestation and should be reconsidered in multiple gestations.
A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants.
TLDR
Preliminary evidence justifies further trials, but that further work is needed before any new routine procedure is established, as there may be an increased risk of fetal death in pregnancies complicated by severe hypertensionedema-proteinuria syndromes and treated with betamethasone.
Different corticosteroids and regimens for accelerating fetal lung maturation for women at risk of preterm birth.
BACKGROUND Despite the widespread use of antenatal corticosteroids to prevent respiratory distress syndrome in preterm infants, there is currently no consensus as to the type of corticosteroid to
Should we be prescribing repeated courses of antenatal corticosteroids?
Antenatal corticosteroids for fetal lung maturation in threatened preterm delivery: indications and administration
TLDR
The evidence to date is clearly against the routine administration of multiple antenatal steroid courses, but in special clinical situations, a second course of betamethasone (“rescue course”) may be justifiable.
Multiple courses of antenatal corticosteroids: a systematic review and meta-analysis.
TLDR
It is not possible to establish the true effects of multiple courses of antenatal corticosteroids by a review of the results of observational studies because of the effect of confounding variables and Randomized controlled trials are needed to address this important issue.
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