Antagonizing the parathyroid calcium receptor stimulates parathyroid hormone secretion and bone formation in osteopenic rats.

Abstract

Parathyroid hormone (PTH) is an effective bone anabolic agent, but it must be administered parenterally. An orally active anabolic agent would provide a valuable alternative for treating osteoporosis. NPS 2143 is a novel, selective antagonist (a "calcilytic") of the parathyroid cell Ca(2+) receptor. Daily oral administration of NPS 2143 to osteopenic… (More)

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Cite this paper

@article{Gowen2000AntagonizingTP, title={Antagonizing the parathyroid calcium receptor stimulates parathyroid hormone secretion and bone formation in osteopenic rats.}, author={Mike Gowen and G. B. Stroup and Rebecca A. Dodds and Ian E. James and Bart J. Votta and B. R. Smith and P. K. Bhatnagar and Amparo M Lago and J. Callahan and E G Delmar and M. A. Miller and Edit Nemeth and J. Fox}, journal={The Journal of clinical investigation}, year={2000}, volume={105 11}, pages={1595-604} }