Antagonists of the antidiuretic activity of vasopressin.

@article{Kinter1988AntagonistsOT,
  title={Antagonists of the antidiuretic activity of vasopressin.},
  author={Lewis B. Kinter and William F. Huffman and Frans L. H. Stassen},
  journal={The American journal of physiology},
  year={1988},
  volume={254 2 Pt 2},
  pages={
          F165-77
        }
}
Competitive antagonists of the antidiuretic (ADH) activity of vasopressin were first described some six years ago. When studied in vitro, ADH antagonists displace vasopressin from specific renal binding sites and antagonize, in a competitive fashion, vasopressin stimulation of adenylate cyclase and transepithelial water, salt, and urea fluxes. When studied in vivo, the ADH antagonists increase renal water excretion and antagonize, in a competitive fashion, the ADH activity of vasopressin… CONTINUE READING
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