Antagonists of GLUK5-containing kainate receptors prevent pilocarpine-induced limbic seizures

Abstract

Developments in the molecular biology and pharmacology of GLUK5, a subtype of the kainate class of ionotropic glutamate receptors, have enabled insights into the roles of this subunit in synaptic transmission and plasticity. However, little is known about the possible functions of GLUK5-containing kainate receptors in pathological conditions. We report here… (More)
DOI: 10.1038/nn880

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