Antagonistic property of buprenorphine for putative ϵ-opioid receptor-mediated G-protein activation by β-endorphin in pons/medulla of the μ-opioid receptor knockout mouse

@article{Mizoguchi2002AntagonisticPO,
  title={Antagonistic property of buprenorphine for putative ϵ-opioid receptor-mediated G-protein activation by $\beta$-endorphin in pons/medulla of the $\mu$-opioid receptor knockout mouse},
  author={Hirokazu Mizoguchi and H.-e. Wu and Minoru Narita and F. Scott Hall and Ichiro Sora and George R. Uhl and Hiroshi Nagase and Leon F. Tseng},
  journal={Neuroscience},
  year={2002},
  volume={115},
  pages={715-721}
}
Buprenorphine Blocks ϵ- and μ-Opioid Receptor-Mediated Antinociception in the Mouse
TLDR
It is concluded that buprenorphine, at small doses, blocks ϵ-opioid receptor-mediated β-endorphin-induced antinociception and μ-opionceptor-mediated DAMGO-inducedAntagonistic properties, and at high doses produces a μ-OPioid receptors-mediated antinOCiception.
Differential mechanism of G-protein activation induced by endogenous mu-opioid peptides, endomorphin and beta-endorphin.
TLDR
The subject of the present review is to focus on the differential mechanism underlying G-protein activation induced by these mu-opioid peptides using the [35S]GTPgammaS binding assay.
Non-opioid actions of opioid peptides.
In vivo and in vitro characterization of naltrindole-derived ligands at the κ-opioid receptor
TLDR
Interestingly, while 5’-AMN and 5'-MABN were not κ-selective, both compounds did show significant antidepressant- and anxiolytic-like effects at 7–14 days post-injection in mice, contrary to the hypothesis.
Effects of beta-endorphin on endothelial/monocytic endothelin-1 and nitric oxide release mediated by mu1-opioid receptors: a potential link between stress and endothelial dysfunction?
TLDR
A role of beta-Endorphin is hypothesized in the pathogenesis of stress-induced endothelial dysfunction through peripherally circulating beta-endorphin, which may offset the balance of vasoactive mediators, leading to an unopposed vasoconstriction.
Recent Advances in the Search for the -Opioidergic System
TLDR
Findings indicate that EM-1 may produce its rewarding effect via MOP-Rs, and the aversive effect induced by EM-2 may be associated with the stimulation of the EM- 1-insensitive Mop-R subtype and necessarily activate an endogenous KOPergic system in the mouse brain.
β-Endorphin Mediates the Development and Instability of Atherosclerotic Plaques
TLDR
This study provides the first evidence that β-endorphin contributes to the acceleration of the progression and instability of atheromatous plaques, and μ-opioid receptor antagonists may be useful for the prevention and treatment of atherosclerosis.
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TLDR
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