Antagonistic property of buprenorphine for putative ϵ-opioid receptor-mediated G-protein activation by β-endorphin in pons/medulla of the μ-opioid receptor knockout mouse

@article{Mizoguchi2002AntagonisticPO,
  title={Antagonistic property of buprenorphine for putative ϵ-opioid receptor-mediated G-protein activation by $\beta$-endorphin in pons/medulla of the $\mu$-opioid receptor knockout mouse},
  author={Hirokazu Mizoguchi and H.-e. Wu and Minoru Narita and F. Scott Hall and Ichiro Sora and George R. Uhl and Hiroshi Nagase and Leon F. Tseng},
  journal={Neuroscience},
  year={2002},
  volume={115},
  pages={715-721}
}
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16 Citations
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16 Citations

Buprenorphine Blocks ϵ- and μ-Opioid Receptor-Mediated Antinociception in the Mouse

It is concluded that buprenorphine, at small doses, blocks ϵ-opioid receptor-mediated β-endorphin-induced antinociception and μ-opionceptor-mediated DAMGO-inducedAntagonistic properties, and at high doses produces a μ-OPioid receptors-mediated antinOCiception.

Loss of μ-opioid receptor-mediated G-protein activation in the pons/medulla of mice lacking the exons 2 and 3 of μ-opioid receptor gene

Differential mechanism of G-protein activation induced by endogenous mu-opioid peptides, endomorphin and beta-endorphin.

The subject of the present review is to focus on the differential mechanism underlying G-protein activation induced by these mu-opioid peptides using the [35S]GTPgammaS binding assay.

Non-opioid actions of opioid peptides.

In vivo and in vitro characterization of naltrindole-derived ligands at the κ-opioid receptor

Interestingly, while 5’-AMN and 5'-MABN were not κ-selective, both compounds did show significant antidepressant- and anxiolytic-like effects at 7–14 days post-injection in mice, contrary to the hypothesis.

No evidence for G-protein-coupled epsilon receptor in the brain of triple opioid receptor knockout mouse.

Recent Advances in the Search for the -Opioidergic System

Findings indicate that EM-1 may produce its rewarding effect via MOP-Rs, and the aversive effect induced by EM-2 may be associated with the stimulation of the EM- 1-insensitive Mop-R subtype and necessarily activate an endogenous KOPergic system in the mouse brain.

Differential effects of gestational buprenorphine, naloxone, and methadone on mesolimbic mu opioid and ORL1 receptor G protein coupling.

β-Endorphin Mediates the Development and Instability of Atherosclerotic Plaques

This study provides the first evidence that β-endorphin contributes to the acceleration of the progression and instability of atheromatous plaques, and μ-opioid receptor antagonists may be useful for the prevention and treatment of atherosclerosis.

mu-Opioid receptor knockout mice display reduced cocaine conditioned place preference but enhanced sensitization of cocaine-induced locomotion.

References

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