Antagonistic property of buprenorphine for putative ϵ-opioid receptor-mediated G-protein activation by β-endorphin in pons/medulla of the μ-opioid receptor knockout mouse

@article{Mizoguchi2002AntagonisticPO,
  title={Antagonistic property of buprenorphine for putative ϵ-opioid receptor-mediated G-protein activation by $\beta$-endorphin in pons/medulla of the $\mu$-opioid receptor knockout mouse},
  author={Hirokazu Mizoguchi and H.-e. Wu and Minoru Narita and F. Scott Hall and Ichiro Sora and George R. Uhl and Hiroshi Nagase and Leon F. Tseng},
  journal={Neuroscience},
  year={2002},
  volume={115},
  pages={715-721}
}
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15 Citations
Background Citations
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15 Citations

Buprenorphine Blocks ϵ- and μ-Opioid Receptor-Mediated Antinociception in the Mouse
TLDR
It is concluded that buprenorphine, at small doses, blocks ϵ-opioid receptor-mediated β-endorphin-induced antinociception and μ-opionceptor-mediated DAMGO-inducedAntagonistic properties, and at high doses produces a μ-OPioid receptors-mediated antinOCiception.
Differential mechanism of G-protein activation induced by endogenous mu-opioid peptides, endomorphin and beta-endorphin.
TLDR
The subject of the present review is to focus on the differential mechanism underlying G-protein activation induced by these mu-opioid peptides using the [35S]GTPgammaS binding assay.
Non-opioid actions of opioid peptides.
In vivo and in vitro characterization of naltrindole-derived ligands at the κ-opioid receptor
TLDR
Interestingly, while 5’-AMN and 5'-MABN were not κ-selective, both compounds did show significant antidepressant- and anxiolytic-like effects at 7–14 days post-injection in mice, contrary to the hypothesis.
No evidence for G-protein-coupled epsilon receptor in the brain of triple opioid receptor knockout mouse.
Effects of beta-endorphin on endothelial/monocytic endothelin-1 and nitric oxide release mediated by mu1-opioid receptors: a potential link between stress and endothelial dysfunction?
TLDR
A role of beta-Endorphin is hypothesized in the pathogenesis of stress-induced endothelial dysfunction through peripherally circulating beta-endorphin, which may offset the balance of vasoactive mediators, leading to an unopposed vasoconstriction.
Recent Advances in the Search for the -Opioidergic System
TLDR
Findings indicate that EM-1 may produce its rewarding effect via MOP-Rs, and the aversive effect induced by EM-2 may be associated with the stimulation of the EM- 1-insensitive Mop-R subtype and necessarily activate an endogenous KOPergic system in the mouse brain.
Differential effects of gestational buprenorphine, naloxone, and methadone on mesolimbic mu opioid and ORL1 receptor G protein coupling.
Selective impairment of spinal mu-opioid receptor mechanism by plasticity of serotonergic facilitation mediated by 5-HT2A and 5-HT2B receptors
β-Endorphin Mediates the Development and Instability of Atherosclerotic Plaques
TLDR
This study provides the first evidence that β-endorphin contributes to the acceleration of the progression and instability of atheromatous plaques, and μ-opioid receptor antagonists may be useful for the prevention and treatment of atherosclerosis.
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References

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β-Endorphin-(1–27) antagonizes β-endorphin- but not morphine-, D-PEN2-D-PEN2-enkephalin- and U50, 488H-induced analgesia in mice
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TLDR
The results suggest that mu-opioid agonist efficacy is determined by the magnitude of the receptor-mediated affinity shift in the binding of GTP (or[35S]GTP gamma S) versus GDP to the G protein and by the number of G proteins activated per occupied receptor.
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TLDR
It is proposed that endomorphin-1 produces antinociception by stimulating one type of mu-opioid receptor, whereas endomorphicin-2 initially stimulates different mu-OPioid receptors, which subsequently induce the release of dynorphins that act on kappa-opIOid receptors to produce antinOCiception.
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TLDR
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TLDR
The ability of the delta opioid agonist DPDPE to stimulate binding of the GTP analog guanosine-5'-O-(3-[35S]thio)triphosphate to pertussis toxin-sensitive G proteins has been characterized in membranes from NG108-15 mouse neuroblastoma X rat glioma cells.
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TLDR
It is concluded that the endomorphins are potent spinal antinociceptive and anti-allodynic agents and that they or related compounds may prove therapeutically useful as spinal analgesics.
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TLDR
It was found that the Ki values closely matched the EC50 values for [35S]GTP gamma S binding stimulation, indicating that a large receptor reserve does not exist for the complete activation of G proteins in this system.
The role of amino-terminal sequence of beta-endorphin and dynorphin in the determination of opiate receptor type selectivity.
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