Antagonistic properties of N-methyl-N'-[2-(5-ethyl-4-imidazolyl-methylthio)ethyl]thiourea.

  title={Antagonistic properties of N-methyl-N'-[2-(5-ethyl-4-imidazolyl-methylthio)ethyl]thiourea.},
  author={T. Vitali and C. Ferrari and G. Bertaccini and M. Impicciatore},
  journal={Il Farmaco; edizione scientifica},
  volume={34 5},
  • T. Vitali, C. Ferrari, +1 author M. Impicciatore
  • Published 1979
  • Chemistry, Medicine
  • Il Farmaco; edizione scientifica
  • In the present paper the Authors describe the synthesis and the biological effects of N-methyl-N'-[2-(5-ethyl-4-imidazolylmethylthio)ethyl]thiourea (etiamide). This compound appeared to inhibit, to a certain extent, the effect of histamine on H2-receptors. This inhibition, however, was less pronounced than that elicited by metiamide and in some of the preparations examined appeared to be of the non-competitive type. 

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