Antagonistic interactions of transforming growth factors in the regulation of granulosa cell differentiation.

@article{Adashi1986AntagonisticIO,
  title={Antagonistic interactions of transforming growth factors in the regulation of granulosa cell differentiation.},
  author={Eli Y Adashi and C E Reshick},
  journal={Endocrinology},
  year={1986},
  volume={119 4},
  pages={1879-81}
}
The role of transforming growth factors (TGFs) in the acquisition of granulosa cell aromatase activity was investigated in vitro in a primary culture of granulosa cells harvested from immature, diethylstilbestrol-treated rats. Basal aromatase activity, as assessed by the generation of radioimmunoassayable estrogen, was negligible, remaining unaffected by treatment with either TGF alpha or TGF beta applied by themselves at the 10 ng/ml dose level. Whereas treatment with FSH produced a… CONTINUE READING
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