Antagonistic interaction between adenosine A2A receptors and dopamine D2 receptors in the ventral striopallidal system. Implications for the treatment of schizophrenia

@article{Ferr1994AntagonisticIB,
  title={Antagonistic interaction between adenosine A2A receptors and dopamine D2 receptors in the ventral striopallidal system. Implications for the treatment of schizophrenia},
  author={S. Ferr{\'e} and W. O'connor and P. Snaprud and U. Ungerstedt and K. Fuxe},
  journal={Neuroscience},
  year={1994},
  volume={63},
  pages={765-773}
}
  • S. Ferré, W. O'connor, +2 authors K. Fuxe
  • Published 1994
  • Chemistry, Medicine
  • Neuroscience
  • Recent studies have shown the existence of a specific antagonistic interaction between adenosine A2a receptors and dopamine D2 receptors in the brain. This A2a-D2 interaction seems to be essential for the behavioural effects of adenosine agonists and antagonists, like caffeine. In the present study quantitative receptor autoradiography and brain microdialysis were combined to demonstrate a powerful antagonistic A2a-D2 interaction in the ventral striopallidal system. In the presence of the A2a… CONTINUE READING
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