Antagonistic gene transcripts regulate adaptation to new growth environments.

  title={Antagonistic gene transcripts regulate adaptation to new growth environments.},
  author={Bridget L. Baumgartner and Matthew R. Bennett and Michael Ferry and Tracy L. Johnson and Lev S. Tsimring and Jeff Hasty},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={108 52},
Cells have evolved complex regulatory networks that reorganize gene expression patterns in response to changing environmental conditions. These changes often involve redundant mechanisms that affect various levels of gene expression. Here, we examine the consequences of enhanced mRNA degradation in the galactose utilization network of Saccharomyces cerevisiae. We observe that glucose-induced degradation of GAL1 transcripts provides a transient growth advantage to cells upon addition of glucose… CONTINUE READING
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