Antagonistic function of the RNA-binding protein HuR and miR-200b in post-transcriptional regulation of vascular endothelial growth factor-A expression and angiogenesis.

@article{Chang2013AntagonisticFO,
  title={Antagonistic function of the RNA-binding protein HuR and miR-200b in post-transcriptional regulation of vascular endothelial growth factor-A expression and angiogenesis.},
  author={Sung-Hee Chang and Yi-Chien Lu and Xi Li and Wan-Ying Hsieh and Yuquan Xiong and Mallika Ghosh and Todd Evans and Olivier Elemento and Timothy Hla},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 7},
  pages={4908-21}
}
HuR, also known as Elavl1, is an RNA-binding protein that regulates embryonic development, progenitor cell survival, and cell stress responses. The role of HuR in angiogenesis is not known. Using a myeloid-specific HuR knock-out mouse model (Elavl1Mø KO), we show that HuR expression in bone marrow-derived macrophages (BMDMs) is needed to maintain the expression of genes enriched in AU-rich elements and U-rich elements in the 3'-UTR. In addition, BMDMs from Elavl1Mø KO mice also showed… CONTINUE READING