Antagonistic effects of doublecortin and MARK2/Par-1 in the developing cerebral cortex.

@article{Sapir2008AntagonisticEO,
  title={Antagonistic effects of doublecortin and MARK2/Par-1 in the developing cerebral cortex.},
  author={Tamar Sapir and Anat Shmueli and Talia Levy and Thomas Timm and Michael Elbaum and E. -M. Mandelkow and Orly Reiner},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2008},
  volume={28 48},
  pages={13008-13}
}
Abnormal neuronal migration is manifested in brain malformations such as lissencephaly. The impairment in coordinated cell motility likely reflects a faulty mechanism of cell polarization or coupling between polarization and movement. Here we report on the relationship between the polarity kinase MARK2/Par-1 and its substrate, the well-known lissencephaly-associated gene doublecortin (DCX), during cortical radial migration. We have previously shown using in utero electroporation that reduced… CONTINUE READING

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Accurate balance of the polarity kinase MARK2/Par-1 is required for proper cortical neuronal migration.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2008
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