Antagonistic effect of l-stepholidine on striatal ischemic injury in rat.

@article{Tang1999AntagonisticEO,
  title={Antagonistic effect of l-stepholidine on striatal ischemic injury in rat.},
  author={Feng Tang and Yun Min Ding and Ying Tsung Chen and Y F Sun and Rui Wang and Guang Yi Zhang and Guang-yi Jin},
  journal={Zhongguo yao li xue bao = Acta pharmacologica Sinica},
  year={1999},
  volume={20 12},
  pages={1073-8}
}
AIM To elucidate the protection of l-stepholidine (SPD) on neuronal morphology and function against the striatal ischemic injury in rat. METHODS The forebrain ishemia to Sprague Dawley rats was induced with four-vessel occlusion. Histological examination was performed on the dorsolateral striatum with cresylviolet stain. In striatal slices of rat as an in vitro ischemic model, the activity of calcium/calmodulin-dependent protein kinase II (CCDPK) and lactate dehydrogenase (LDH) was examined… CONTINUE READING