Antagonistic cross-regulation between Wnt and Hedgehog signalling pathways controls post-embryonic retinal proliferation.

@article{Borday2012AntagonisticCB,
  title={Antagonistic cross-regulation between Wnt and Hedgehog signalling pathways controls post-embryonic retinal proliferation.},
  author={Caroline Borday and Pauline Cabochette and K. Parain and Nicolas Mazurier and Sylvie Janssens and Hong Thi Tran and Bela{\"i}d Sekkali and Odile J. Bronchain and Kris Vleminckx and Morgane Locker and Muriel Perron},
  journal={Development},
  year={2012},
  volume={139 19},
  pages={3499-509}
}
Continuous neurogenesis in the adult nervous system requires a delicate balance between proliferation and differentiation. Although Wnt/β-catenin and Hedgehog signalling pathways are thought to share a mitogenic function in adult neural stem/progenitor cells, it remains unclear how they interact in this process. Adult amphibians produce retinal neurons from a pool of neural stem cells localised in the ciliary marginal zone (CMZ). Surprisingly, we found that perturbations of the Wnt and Hedgehog… CONTINUE READING
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