Antagonistic and synergistic effects of bone morphogenetic protein 2/7 and all‐trans retinoic acid on the osteogenic differentiation of rat bone marrow stromal cells

@article{Bi2013AntagonisticAS,
  title={Antagonistic and synergistic effects of bone morphogenetic protein 2/7 and all‐trans retinoic acid on the osteogenic differentiation of rat bone marrow stromal cells},
  author={Wen-juan Bi and Zhiyuan Gu and Yuanna Zheng and Limin Wang and Jing Guo and Gang Wu},
  journal={Development},
  year={2013},
  volume={55}
}
The osteogenesis of bone marrow stromal cells (BMSCs) is of paramount importance for the repair of large‐size bone defects, which may be compromised by the dietary‐accumulated all‐trans retinoic acid (ATRA). We have shown that heterodimeric bone morphogenetic protein 2/7 (BMP2/7) could induce bone regeneration in a significantly higher dose‐efficiency in comparison with homodimeric BMPs. In this study, we evaluated the effects of ATRA and BMP2/7 on the proliferation, differentiation… 
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TLDR
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The role of Serpina3n in the reversal effect of ATRA on dexamethasone-inhibited osteogenic differentiation in mesenchymal stem cells
  • Hai-Tao Jiang, R. Deng, +7 authors Z. Deng
  • Medicine
    Stem cell research & therapy
  • 2021
TLDR
ATRA can reverse DEX-inhibited osteogenic differentiation both in vitro and in vivo, which may be closely related to the downregulation ofDEX-promoted Serpina3n and may act as a new target for GIOP.
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TLDR
In vitro and in vivo functional characteristics of BMPs of different dimerization types are evaluated with the aim of determining osteoinductive efficiency of heterodimeric BMP‐2/7 on osteogenesis of hASCs.
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TLDR
The literature is reviewed, paying attention to the prospects of existing approved small molecule therapeutics with bone regenerative capacity, and some of these small molecules with osteoinductive potential have been approved for human use due to their efficacy in treating other health ailments.
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