Antagonistic adrenergic-muscarinic regulation of M current in smooth muscle cells.

@article{Sims1988AntagonisticAR,
  title={Antagonistic adrenergic-muscarinic regulation of M current in smooth muscle cells.},
  author={Stephen Michael Sims and Joshua A. Singer and John V. Walsh},
  journal={Science},
  year={1988},
  volume={239 4836},
  pages={190-3}
}
The beta-adrenergic agonist isoproterenol and analogs of adenosine 3',5'-monophosphate (cAMP) induced a potassium current, M current, in freshly dissociated gastric smooth muscle cells. Muscarinic agonists suppress this current, apparently by acting at a locus downstream from regulation of cAMP levels by adenylate cyclase and phosphodiesterase. Thus, M current can be induced by an agent and regulated in antagonistic fashion by beta-adrenergic and muscarinic systems. 
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