Antagonistic actions of Msx1 and Osr2 pattern mammalian teeth into a single row.

@article{Zhang2009AntagonisticAO,
  title={Antagonistic actions of Msx1 and Osr2 pattern mammalian teeth into a single row.},
  author={Zunyi Zhang and Yu Lan and Yang Chai and Rulang Jiang},
  journal={Science},
  year={2009},
  volume={323 5918},
  pages={1232-4}
}
Mammals have single-rowed dentitions, whereas many nonmammalian vertebrates have teeth in multiple rows. Neither the molecular mechanism regulating iterative tooth initiation nor that restricting mammalian tooth development in one row is known. We found that mice lacking the transcription factor odd-skipped related-2 (Osr2) develop supernumerary teeth lingual to their molars because of expansion of the odontogenic field. Osr2 was expressed in a lingual-to-buccal gradient and restricted… CONTINUE READING