Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor/.NO through a radical reaction.

@article{Akaike1993AntagonisticAO,
  title={Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor/.NO through a radical reaction.},
  author={Takaaki Akaike and Michiteru Yoshida and Yutaka Miyamoto and Katsuko Sato and Masahiro Kohno and Kazushige Sasamoto and Kentaro Miyazaki and Shiro Ueda and Hidekatsu Maeda},
  journal={Biochemistry},
  year={1993},
  volume={32 3},
  pages={827-32}
}
A labile inorganic free radical, nitric oxide (.NO), is produced by nitric oxide synthase from the substrate L-arginine in various cells and tissues. It acts as an endothelium-derived relaxing factor (EDRF) or as a neurotransmitter in vivo. We investigated the reactivity of stable radical compounds, imidazolineoxyl N-oxides such as 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide (PTIO), carboxy-PTIO, and carboxymethoxy-PTIO against .NO/EDRF in both chemical and biological systems. By… CONTINUE READING
Highly Influential
This paper has highly influenced 18 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 114 extracted citations

Similar Papers

Loading similar papers…