Antagonistic Effect of Pseudoginsenoside-F11 on the Behavioral Actions of Morphine in Mice

@article{Li2000AntagonisticEO,
  title={Antagonistic Effect of Pseudoginsenoside-F11 on the Behavioral Actions of Morphine in Mice},
  author={Zhuo-xuan Li and Chun-Fu Wu and Gang Pei and Yue Y Guo and Xian Li},
  journal={Pharmacology Biochemistry and Behavior},
  year={2000},
  volume={66},
  pages={595-601}
}
The antagonistic effect of pseudoginoside-F11 (PF(11)) on the various actions of morphine was studied in mice. The results demonstrated that PF(11), at the doses of 4 and 8 mg/kg, PO, significantly inhibited morphine (10 mg/kg, SC)-induced memory impairment in the Morris water maze test. PF(11), at 4 mg/kg, PO, did not influence conditioned place preference per se, yet markedly blocked the conditioned place preference to morphine. PF(11), at the doses of 4 and 8 mg/kg, PO, also significantly… 
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