Antagonist-precipitated opioid withdrawal in rats: evidence for dissociations between physical and motivational signs.

@article{Higgins1994AntagonistprecipitatedOW,
  title={Antagonist-precipitated opioid withdrawal in rats: evidence for dissociations between physical and motivational signs.},
  author={Guy A Higgins and Edward M. Sellers},
  journal={Pharmacology, biochemistry, and behavior},
  year={1994},
  volume={48 1},
  pages={1-8}
}
In rats made opioid dependent by the implantation of a single morphine 75 mg base pellet, an attempt was made to determine whether any correlational existed between physical and motivational withdrawal signs by adjusting the dose of naloxone used to precipitate withdrawal. The models used to study motivational signs were taste (one- and two-bottle) conditioning and operant responding for food under an FR15 schedule of reinforcement. Naloxone at doses of 0.01 mg/kg and above produced both a… CONTINUE READING

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