Antagonist of microRNA‐21 improves balloon injury‐induced rat iliac artery remodeling by regulating proliferation and apoptosis of adventitial fibroblasts and myofibroblasts

@article{Wang2012AntagonistOM,
  title={Antagonist of microRNA‐21 improves balloon injury‐induced rat iliac artery remodeling by regulating proliferation and apoptosis of adventitial fibroblasts and myofibroblasts},
  author={Fei Wang and Xue-qiang Zhao and Jun-ni Liu and Zhi-hao Wang and Xiu-ling Wang and Xiao-Yang Hou and Rong Liu and Fei Gao and Ming-Xiang Zhang and Yun Zhang and Pei-li Bu},
  journal={Journal of Cellular Biochemistry},
  year={2012},
  volume={113}
}
Molecular pathways involved in adventitial fibroblasts (AFs) and myofibroblasts (MFs) proliferation and apoptosis contribute to vascular remodeling. MicroRNA‐21 (miR‐21) plays an important role in regulating cellular proliferation and apoptosis of many cell types; however, the effect of miR‐21 on AFs and MFs is still unknown. In this study, we found that miR‐21 was expressed in AFs and overexpressed in MFs. Inhibition of miR‐21 decreased proliferation and increased apoptosis of AFs and MFs, and… 
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