Antagonist-occupied human progesterone B-receptors activate transcription without binding to progesterone response elements and are dominantly inhibited by A-receptors.

@article{Tung1993AntagonistoccupiedHP,
  title={Antagonist-occupied human progesterone B-receptors activate transcription without binding to progesterone response elements and are dominantly inhibited by A-receptors.},
  author={Lin Tung and Mostfa K Mohamed and James P. Hoeffler and Glenn S Takimoto and Kathryn B. Horwitz},
  journal={Molecular endocrinology},
  year={1993},
  volume={7 10},
  pages={1256-65}
}
When antagonist-occupied steroid receptors have agonist-like effects, the clinical consequences are grave. We present evidence that human progesterone B-receptors (hPRB) when occupied by progesterone antagonists, inappropriately activate transcription by an unusual mechanism that does not require the canonical progesterone response element (PRE). In HeLa cells cotransfected with a PRE-tk-chloramphenicol acetyltransferase reporter and a hPRB expression vector, strong transcription is seen not… CONTINUE READING