Antagonist drug selectivity for radioligand binding sites on voltage-gated and N-methyl-d-aspartate receptor-gated Ca2+ channels

@article{Jaffe1989AntagonistDS,
  title={Antagonist drug selectivity for radioligand binding sites on voltage-gated and N-methyl-d-aspartate receptor-gated Ca2+ channels},
  author={Drusilla B. Jaffe and Shelley S. Marks and D. A. Greenberg},
  journal={Neuroscience Letters},
  year={1989},
  volume={105},
  pages={227-232}
}
Drugs that block voltage-gated Ca2+ channels or N-methyl-D-aspartate receptor-gated channels have been shown to reduce experimental hypoxic-ischemic neuronal injury. To determine if any such compounds interact with both types of channels, and might therefore be prototypes for new anti-ischemic drugs with dual therapeutic actions, we compared the affinities of channel blockers for voltage-gated Ca2+ channel binding sites labeled by (+)-[3H]PN 200-110 and N-methyl-D-aspartate receptor-gated… CONTINUE READING