• Corpus ID: 25903254

Antagonism of xylazine sedation in steers by doxapram and 4-aminopyridine.

@article{Zahner1984AntagonismOX,
  title={Antagonism of xylazine sedation in steers by doxapram and 4-aminopyridine.},
  author={J M Zahner and Roger C. Hatch and R. C. Wilson and Nicholas H. Booth and Joseph V. Kitzman and J D Brown},
  journal={American journal of veterinary research},
  year={1984},
  volume={45 12},
  pages={
          2546-51
        }
}
Five groups of 6 fasted crossbred steers were injected IM with standard dosages of xylazine hydrochloride (0.3 to 0.5 mg/kg). At maximal sedation, the steers were injected IV with the antagonists' doxapram (1.0 mg/kg), doxapram + yohimbine (0.125 mg of yohimbine/kg), doxapram + 4-aminopyridine (4-AP; 0.3 mg of 4-AP/kg), or 4-AP + yohimbine. One group was given 1.0 ml of saline solution IV instead of antagonists. Doxapram, doxapram + yohimbine, doxapram + 4-AP, and 4-AP + yohimbine decreased… 
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塩 酸 キ シ ラ ジ ソ 〔2-(2,6-dimethyphenyl amino)-4-H-5,6-dihydro-1,3-thiazinehydrochloride〕 は,1962年 西 ドイ ツバ イエ ル 社 で 合 成 され た 鎮 静,鎮 痛,筋 弛 緩 剤 で あ り,豚 を 除 く各 種 動 物 に お い て単 独 あ るい は 麻 酔 剤 と の併 用 に よ り広 く使 用
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Atipamezole effectively reversed medetomidine- and xylazine-associated sedative and cardiopulmonary effects in calves, although medetamidine administration resulted in increases in systemic arterial blood pressures.
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