• Corpus ID: 25903254

Antagonism of xylazine sedation in steers by doxapram and 4-aminopyridine.

  title={Antagonism of xylazine sedation in steers by doxapram and 4-aminopyridine.},
  author={J M Zahner and Roger C. Hatch and R. C. Wilson and Nicholas H. Booth and Joseph V. Kitzman and J D Brown},
  journal={American journal of veterinary research},
  volume={45 12},
Five groups of 6 fasted crossbred steers were injected IM with standard dosages of xylazine hydrochloride (0.3 to 0.5 mg/kg). At maximal sedation, the steers were injected IV with the antagonists' doxapram (1.0 mg/kg), doxapram + yohimbine (0.125 mg of yohimbine/kg), doxapram + 4-aminopyridine (4-AP; 0.3 mg of 4-AP/kg), or 4-AP + yohimbine. One group was given 1.0 ml of saline solution IV instead of antagonists. Doxapram, doxapram + yohimbine, doxapram + 4-AP, and 4-AP + yohimbine decreased… 
Comparative pharmacokinetics of yohimbine in steers, horses and dogs.
Between-species comparisons indicated that the mean area under the serum concentration versus time curve was significantly greater in dogs than in horses, which may explain why steers, horses, and dogs given certain sedatives and anesthetics do not relapse when aroused by an intravenous injection of yohimbine hydrochloride.
Clinical evaluation of R 51163, a new sedative in cattle.
The data suggest possible increased responsiveness to the drug at the time of calving after transport and regrouping of cattle which had only been handled occasionally and manipulations and minor interventions.
Comparative studies on cardiovascular, respiratory and gastrointestinal effects of the sedatives R 51163 and xylazine in cattle
Both R 51163 and xylazine produced modest cardiovascular and respiratory effects that have limited consequences in normal fasted cattle, but should be taken into account in diseased non‐fasted cattle with impaired cardiovascular functions.
Xylazine and its antagonists.
塩 酸 キ シ ラ ジ ソ 〔2-(2,6-dimethyphenyl amino)-4-H-5,6-dihydro-1,3-thiazinehydrochloride〕 は,1962年 西 ドイ ツバ イエ ル 社 で 合 成 され た 鎮 静,鎮 痛,筋 弛 緩 剤 で あ り,豚 を 除 く各 種 動 物 に お い て単 独 あ るい は 麻 酔 剤 と の併 用 に よ り広 く使 用
Management of intraoperative and postoperative anesthetic complications in ruminants and swine.
  • T. Riebold
  • Medicine
    The Veterinary clinics of North America. Food animal practice
  • 1986
Sedative and cardiopulmonary effects of medetomidine hydrochloride and xylazine hydrochloride and their reversal with atipamezole hydrochloride in calves.
Atipamezole effectively reversed medetomidine- and xylazine-associated sedative and cardiopulmonary effects in calves, although medetamidine administration resulted in increases in systemic arterial blood pressures.
Xylazine--a review of its pharmacology and use in veterinary medicine.