Antagonism of warfarin-induced hypoprothrombinemia with use of low-dose subcutaneous vitamin K1.

@article{Fetrow1997AntagonismOW,
  title={Antagonism of warfarin-induced hypoprothrombinemia with use of low-dose subcutaneous vitamin K1.},
  author={C W Fetrow and T Overlock and Laura Leff},
  journal={Journal of clinical pharmacology},
  year={1997},
  volume={37 8},
  pages={751-7}
}
Historically, oral or intravenous doses of vitamin K1 for supratherapeutic anticoagulation have ranged from 10 mg to 50 mg. Intravenous administration of vitamin K1 carries a rare but serious risk. No data specifically confirm the use of low-dose subcutaneous vitamin K1 for warfarin induced hypoprothrombinemia. The aim of this study was twofold: 1) to test the general utility of recommendations put forth by the Third Conference of Antithrombotic Therapy, and 2) to test the reliability of the… CONTINUE READING