• Medicine
  • Published in Psychopharmacology 1990

Antagonism of the hypothermic effect of clozapine in mice by centrally-active alpha 2-adrenergic antagonists and alpha 1-adrenergic agonists.

@article{Menon1990AntagonismOT,
  title={Antagonism of the hypothermic effect of clozapine in mice by centrally-active alpha 2-adrenergic antagonists and alpha 1-adrenergic agonists.},
  author={M. K. Krishna Menon and R. L. Lloyd and L. Jaime Fitten},
  journal={Psychopharmacology},
  year={1990},
  volume={101 1},
  pages={
          67-72
        }
}
Hypothermia induced by either clozapine or clonidine in mice was blocked by the alpha 2-adrenergic antagonists yohimbine, idazoxan, CH-38083, SKF 86466, and L-657,743. These effects were dose related, and the ID50 values for inhibition of clozapine- or clonidine-induced hypothermia were fairly comparable. The order of potency for blocking clonidine-induced hypothermia was: L-657,743 greater than CH-38083 greater than yohimbine greater than idazoxan greater than SKF 86466. A very similar… CONTINUE READING