Antagonism of the effects of tremorine by tropine derivatives.

Abstract

Methods of testing new drugs for anti-Parkinson activity are briefly reviewed. The production in animals of Parkinson-like effects by Tremorine (1,4-dipyrrolidin-1'-ylbut-2-yne), and the inhibition of these effects in mice by a number of tropine derivatives, are described. No correlation was found between the activity against tremor and the anticholinergic, antihistaminic or local anaesthetic properties of the compounds.

Statistics

0200400600'86'89'92'95'98'01'04'07'10'13'16
Citations per Year

695 Citations

Semantic Scholar estimates that this publication has 695 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Farquharson1959AntagonismOT, title={Antagonism of the effects of tremorine by tropine derivatives.}, author={Margaret Farquharson and Rodney G.K. Johnston}, journal={British journal of pharmacology and chemotherapy}, year={1959}, volume={14}, pages={559-66} }