Antagonism of the discriminative stimulus effects of cocaine at two training doses by dopamine D2-like receptor antagonists

@article{Costanza2001AntagonismOT,
  title={Antagonism of the discriminative stimulus effects of cocaine at two training doses by dopamine D2-like receptor antagonists},
  author={Rino M. Costanza and David J. Barber and Philip Terry},
  journal={Psychopharmacology},
  year={2001},
  volume={158},
  pages={146-153}
}
Abstract. Rationale: The relative contributions of different dopamine receptor subtypes to the discriminative stimulus effects of cocaine may be influenced by the training dose of cocaine. Substitution tests with dopamine receptor agonists have suggested that the role of dopamine D2-like receptors is diminished relative to that of D1-like receptors at a training dose of 3 mg/kg cocaine compared with a training dose of 10 mg/kg. Objectives: To test whether dopamine D2-like receptor antagonists… 
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