Antagonism of the STING Pathway via Activation of the AIM2 Inflammasome by Intracellular DNA.

@article{Corrales2016AntagonismOT,
  title={Antagonism of the STING Pathway via Activation of the AIM2 Inflammasome by Intracellular DNA.},
  author={Leticia Corrales and Seng-Ryong Woo and Jason B Williams and Sarah M. McWhirter and Thomas W Dubensky and Thomas F Gajewski},
  journal={Journal of immunology},
  year={2016},
  volume={196 7},
  pages={3191-8}
}
Recent evidence has indicated that innate immune sensing of cytosolic DNA in dendritic cells via the host STING pathway is a major mechanism leading to spontaneous T cell responses against tumors. However, the impact of the other major pathway triggered by intracellular DNA, the absent in melanoma 2 (AIM2) inflammasome, on the functional output from the stimulator of IFN genes (STING) pathway is poorly understood. We found that dendritic cells and macrophages deficient in AIM2, apoptosis… CONTINUE READING
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