Antagonism of serotonin3 (5-HT3) receptors within the blood-brain barrier prevents cisplatin-induced emesis in dogs.

@article{Gidda1995AntagonismOS,
  title={Antagonism of serotonin3 (5-HT3) receptors within the blood-brain barrier prevents cisplatin-induced emesis in dogs.},
  author={Jas Gidda and David C. Evans and Marlene L. Cohen and David T. Wong and David W. Robertson and C J Parli},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1995},
  volume={273 2},
  pages={695-701}
}
Recently discovered serotonin3 (5-HT3) receptor antagonists are potent antiemetics in cytotoxic drug-induced vomiting. The specific site where 5-HT3 receptor antagonists act to abolish emesis is controversial. The major objective of this study was to determine whether the antiemetic effect of 5-HT3 receptor antagonists is exerted in the brain areas that reside inside or outside of the blood-brain barrier. Tropisetron, zatosetron (LY277359 maleate) and its quaternary analog zatosetron-QUAT were… CONTINUE READING

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