Antagonism of serotonergic 5-HT2A/2C receptors: mutual improvement of sleep, cognition and mood?

@article{Landolt2009AntagonismOS,
  title={Antagonism of serotonergic 5-HT2A/2C receptors: mutual improvement of sleep, cognition and mood?},
  author={H P Landolt and Renate Wehrle},
  journal={The European journal of neuroscience},
  year={2009},
  volume={29 9},
  pages={1795-809}
}
Serotonin [5-hydroxytryptamine (5-HT)] and 5-HT receptors are involved in sleep and in waking functions such as cognition and mood. Animal and human studies support a particular role for the 5-HT(2A) receptor in sleep, which has led to renewed interest in this receptor subtype as a target for the development of novel pharmacological agents to treat insomnia. Focusing primarily on findings in healthy human volunteers, a review of the available data suggests that antagonistic interaction with 5… CONTINUE READING
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