Antagonism of serotonergic 5‐HT2A/2C receptors: mutual improvement of sleep, cognition and mood?

  title={Antagonism of serotonergic 5‐HT2A/2C receptors: mutual improvement of sleep, cognition and mood?},
  author={Hans-Peter Landolt and Renate Wehrle},
  journal={European Journal of Neuroscience},
Serotonin [5‐hydroxytryptamine (5‐HT)] and 5‐HT receptors are involved in sleep and in waking functions such as cognition and mood. Animal and human studies support a particular role for the 5‐HT2A receptor in sleep, which has led to renewed interest in this receptor subtype as a target for the development of novel pharmacological agents to treat insomnia. Focusing primarily on findings in healthy human volunteers, a review of the available data suggests that antagonistic interaction with 5… 

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