Antagonism of myostatin enhances muscle regeneration during sarcopenia.

  title={Antagonism of myostatin enhances muscle regeneration during sarcopenia.},
  author={Victoria Siriett and M{\^o}nica Senna Salerno and Carole J Berry and Gina D Nicholas and Rob G Bower and Ravi Kambadur and Mridula Sharma},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  volume={15 8},
A reduction in muscle mass and strength is often observed with aging, and this phenomenon is known as sarcopenia. This age-related atrophy frequently correlates with insufficient levels of muscle regeneration resulting from impairment of satellite cell involvement and myogenesis brought about by the aged environment. Using myostatin-null mice, we recently showed that negative regulators of muscle mass such as myostatin play an active role in the regulation of myogenesis during aging. The… CONTINUE READING