Antagonism of metergoline on the diuretic effect of cyclazocine and U-50488 drugs with a kappa agonist activity.

@article{Gavend1993AntagonismOM,
  title={Antagonism of metergoline on the diuretic effect of cyclazocine and U-50488 drugs with a kappa agonist activity.},
  author={M. Gavend and M. Mallaret and F. Caron and G. Baragatti},
  journal={Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie},
  year={1993},
  volume={47 8},
  pages={
          337-44
        }
}
  • M. Gavend, M. Mallaret, +1 author G. Baragatti
  • Published 1993
  • Biology, Medicine
  • Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
  • In rats receiving a normal saline load of 2.5 ml/100 g, sc, (moderately hydrated rats), injections of the serotonin (5-HT) antagonist, metergoline (0.25-1-4 mg/kg), resulted in a dose-dependent decrease in the urine output induced by a dose of 8 mg/kg of cyclazocine (a benzomorphan derivative, mixed kappa and sigma agonist) at the 2-h time period. The antagonist effect of metergoline (1 mg/kg) on cyclazocine doses ranging from 0.25 to 8 mg/kg, was observed only at 2 mg/kg higher doses. Other 5… CONTINUE READING
    2 Citations
    Endogenous opiates: 1993
    • 52

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