Antagonism of metergoline on the diuretic effect of cyclazocine and U-50488 drugs with a kappa agonist activity.

  title={Antagonism of metergoline on the diuretic effect of cyclazocine and U-50488 drugs with a kappa agonist activity.},
  author={M. Gavend and M. Mallaret and F. Caron and G. Baragatti},
  journal={Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie},
  volume={47 8},
  • M. Gavend, M. Mallaret, +1 author G. Baragatti
  • Published 1993
  • Biology, Medicine
  • Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
  • In rats receiving a normal saline load of 2.5 ml/100 g, sc, (moderately hydrated rats), injections of the serotonin (5-HT) antagonist, metergoline (0.25-1-4 mg/kg), resulted in a dose-dependent decrease in the urine output induced by a dose of 8 mg/kg of cyclazocine (a benzomorphan derivative, mixed kappa and sigma agonist) at the 2-h time period. The antagonist effect of metergoline (1 mg/kg) on cyclazocine doses ranging from 0.25 to 8 mg/kg, was observed only at 2 mg/kg higher doses. Other 5… CONTINUE READING
    2 Citations
    Endogenous opiates: 1993
    • 52


    Studies on the nature and mechanism of the diuretic activity of the opioid analgesic ethylketocyclazocine.
    • 112
    Diuretic effect of bremazocine, a kappa-opioid with central and peripheral sites of action.
    • 23
    Diuretic actions in man of a selective kappa opioid agonist: U-62,066E.
    • 71
    Mechanism of diuretic action of spiradoline (U-62066E)--a kappa opioid receptor agonist in the human.
    • 40
    Inhibition of ADH release in the rat by narcotic antagonists.
    • M. Miller
    • Biology, Medicine
    • Neuroendocrinology
    • 1975
    • 42
    Effects of the highly selective kappa opioid, U-50, 488, on renal function in the anesthetized dog.
    • 38
    Further study of kappa opioids on increased urination.
    • J. Leander
    • Medicine
    • The Journal of pharmacology and experimental therapeutics
    • 1983
    • 97