Antagonism of corticotropin-releasing factor receptors in the locus coeruleus attenuates shock-induced freezing in rats.

Intracerebroventricularly administered alpha-helical CRF9-41, a corticotropin-releasing factor (CRF) receptor antagonist, is known to reduce a variety of stress-induced behavioral responses. This study examined in rats whether antagonism of CRF receptors in the region of locus coeruleus (LC) plays a role in reducing freezing induced by electric foot shock… CONTINUE READING