Antagonism of cisplatin-induced emesis by metoclopramide and dazopride through enhancement of gastric motility

@article{Alphin2005AntagonismOC,
  title={Antagonism of cisplatin-induced emesis by metoclopramide and dazopride through enhancement of gastric motility},
  author={Robert S. Alphin and Anthony George Proakis and C. A. Leonard and W Lamar Smith and Warren Nathaniel Dannenburg and W. J. Kinnier and D. N. Johnson and LAWRENCE F. Sancilio and John W. Ward},
  journal={Digestive Diseases and Sciences},
  year={2005},
  volume={31},
  pages={524-529}
}
The antiemetic activity, gastric motor activity, and dopamine receptor effects of metoclopramide, dazopride, and sulpiride were assessed to establish if enhancement of gastric motility or antagonism of central dopamine receptors is the predominant action for drug-induced suppression of cisplatin-induced emesis. Emesis produced in dogs by cisplatin is antagonized by metoclopramide and dazopride. The antiemetic actions of metoclopramide and dazopride are associated with their ability to enhance… Expand
Pharmacological Agents Affecting Emesis
TLDR
Radiation therapy appears to be similar to cytotoxic therapy in that the mediators produced or released by radiation activate both peripheral and central sites involved in the vomiting reflex. Expand
Neurokinin‐1 receptor blocker CP‐99 994 improved emesis induced by cisplatin via regulating the activity of gastric distention responsive neurons in the dorsal motor nucleus of vagus and enhancing gastric motility in rats
TLDR
The role of NK1 receptor blocker, CP‐99 994, when administrated into dorsal motor nucleus of vagus (DMNV), on the cisplatin‐induced emesis in rats and the possible mechanism is examined. Expand
Efficacy of maropitant for treatment and prevention of emesis caused by intravenous infusion of cisplatin in dogs.
TLDR
Results suggest that maropitant is safe and effective in the treatment and prevention of cisplatin-induced emesis in dogs. Expand
Dose-ranging evaluation of the substituted benzamide dazopride when used as an antiemetic in patients receiving anticancer chemotherapy
TLDR
Dazopride, a substituted benzamide structurally related to metoclopramide, is a potent gastric prokinetic agent that prevents cisplatin-induced emesis in animals and can be safely given at doses of up to 4.0 mg/kg to patients receiving chemotherapy. Expand
Effect of anticholinergics (atropine, glycopyrrolate) and prokinetics (metoclopramide, cisapride) on gastric motility in beagles and labrador retrievers.
TLDR
The effect of atropine, glycopyrrolate, metoclopramide and cisapride on the antral motility was investigated in eight dogs using passive telemetry and it is not clear if the different results in Labradors and Beagles are because of breed or body weight. Expand
Pharmacological Agents Affecting Emesis
TLDR
The use of dopamine receptor antagonists in controlling emesis induced by dopamine agonists used in Parkinson’s disease poses theoretical problems which can be overcome by using drugs with selectivity for the chemoreceptor trigger zone, such as domperidone or metoclopramide. Expand
A History of Drug Discovery for Treatment of Nausea and Vomiting and the Implications for Future Research
TLDR
The repurposing of different drugs for treatment of nausea and vomiting is examined, particularly during palliative care, and also the challenges in identifying novel anti-emetic drugs, particularly for Treatment of nausea as compared to vomiting. Expand
Which antiemetic?
The choice of antiemetic should not be arbitrary, but should be based on knowledge of the different pathways of the various stimuli that lead to nausea and vomiting and the neuroreceptors involved.Expand
Emesis in dogs: a review INTRODUCTION
TLDR
The physiology of the vomiting refl ex, causes of emesis, the consequences ofEmesis and the approach to clinical management of the vomit dog are outlined, and the applicability of diagnostic testing modalities and the merit of traditional approaches to management, such as dietary changes, are discussed. Expand
Emesis in dogs: a review
TLDR
The physiology of the vomiting reflex, causes ofEmesis, the consequences of emesis and the approach to clinical management of the vomit dog are outlined, and the applicability of diagnostic testing modalities and the merit of traditional approaches to management are discussed. Expand
...
1
2
...

References

SHOWING 1-10 OF 26 REFERENCES
Antagonism of cisplatin induced emesis in the dog.
TLDR
Metoclopramide (1, 3 mg/kg sc) was found to be the most effective antagonsit of Cisplatin emesis in the dog while haloperidol and chlorpromazine offered less complete protection. Expand
Antagonism of cisplatin induced emesis in the dog.
TLDR
Metoclopramide was found to be the most effective antagonsit of Cisplatin emesis in the dog while haloperidol and chlorpromazine offered a less complete protection. Expand
Metoclopramide. An updated review of its pharmacological properties and clinical use.
TLDR
Metoclopramide has been confirmed as an effective drug in treating and preventing various types of vomiting and as a useful agent in oesophageal reflux disease, gastroparesis, dyspepsia, and in a variety of functional gastrointestinal disorders. Expand
Metoclopramide. A review of antiemetic trials.
TLDR
Uncontrolled observations of continued metoclopramide treatment during subsequent courses of cisplatin suggest preservation of antiemetic efficacy, and preliminary results of studies of metoclobramide in non-cisplatin-containing regimens suggest benefit. Expand
The control of chemotherapy-induced emesis.
TLDR
At present phenothiazines are the only class of antiemetics that have shown both efficacy and safety in large numbers of cancer patients, but they are inadequate against strongly emetic agents such as cisplatin. Expand
Effects of central acting drugs on serum and pituitary prolactin levels in rats.
TLDR
A single intraperitoneal injection of reserpine, chlorpromazine, C, alphamethyl- para-tyrosine and AMPT in proestrous rats produced profound elevations in serum prolactin 30 min to 4 hr after injection, which indicates that these 4 drugs evoked rapid release of Prolactin from the pituitary, and that AMMT also elicited rapid synthesis of prolACTin. Expand
Spiperone: a ligand of choice for neuroleptic receptors. 1. Kinetics and characteristics of in vitro binding.
TLDR
It is concluded that spiperone is a more suitable ligand than haloperidol for studying the neuroleptic receptors. Expand
Effect of sulpiride on plasma prolactin in rats.
TLDR
The results suggest that S stimulates Prl secretion by its possible direct action on the anterior pituitary by itsossible direct action in response to L-dopa administration and Hypothalamic destruction. Expand
Is there a relationship between the involvement of extrapyramidal and mesolimbic brain areas with the cataleptic action of neuroleptic agents and their clinical antipsychotic effect?
TLDR
The electrolytic brain lesion technique was used in the rat to disrupt the ascending dopaminergic pathways to the extrapyramidal and mesolimbic brain areas in the lateral hypothalamus and the pathways to those areas only in the rostral hypothalamus to reduce the cataleptic ability of all neuroleptics tested in the chronic stage. Expand
Dopamine Receptors: A Classification
  • I. Creese, S. Leff
  • Psychology, Medicine
  • Journal of clinical psychopharmacology
  • 1982
TLDR
Guanine nucleotides shift this equilibrium toward the low affinity state, and they likely play an important role in the regulation of dopamine agonist-stimulated physiological responses. Expand
...
1
2
3
...