Antagonism of arachidonic acid is linked to the antitumorigenic effect of dietary eicosapentaenoic acid in Apc(Min/+) mice.

@article{Petrik2000AntagonismOA,
  title={Antagonism of arachidonic acid is linked to the antitumorigenic effect of dietary eicosapentaenoic acid in Apc(Min/+) mice.},
  author={Melissa B. Hansen Petrik and Michael F. McEntee and Chun Hung Chiu and Jay Whelan},
  journal={The Journal of nutrition},
  year={2000},
  volume={130 5},
  pages={1153-8}
}
The multiple intestinal neoplasia (Apc(Min/+)) mouse possesses a germline mutation at codon 850 of the adenomatous polyposis coli (Apc) gene resulting in the formation of a nonfunctional truncated gene product. Following a somatic mutation of the remaining wild-type allele, mice spontaneously develop approximately 40-50 tumors throughout the intestinal tract. This mouse model has been used to study intestinal tumorigenesis because this mutation is analogous to the inherited APC mutation in… CONTINUE READING
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