Antagonism of TRPV1 receptors indirectly modulates activity of thermoregulatory neurons in the medial preoptic area of rats.

@article{McGaraughty2009AntagonismOT,
  title={Antagonism of TRPV1 receptors indirectly modulates activity of thermoregulatory neurons in the medial preoptic area of rats.},
  author={Steve P McGaraughty and Jason A. Segreti and Ryan M. Fryer and Brian S Brown and Connie R. Faltynek and Philip R. Kym},
  journal={Brain research},
  year={2009},
  volume={1268},
  pages={
          58-67
        }
}
In order to enhance understanding of TRPV1 contributions to thermoregulation, we measured the effects of a TRPV1 receptor antagonist, A-889425, on thermoregulatory neurons in the medial preoptic area of the hypothalamus (mPOA) of rats while simultaneously monitoring rectal temperature (T(r)). Administration of A-889425 (4 micromol/kg, i.v.) significantly increased T(r) by 0.42+/-0.02 degrees C in anesthetized rats. Warm-sensitive (WS) neurons in the mPOA increase firing in response to body… CONTINUE READING

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