Antagonism of Secreted PCSK 9 Increases Low Density Lipoprotein Receptor Expression in HepG 2 Cells *

@inproceedings{McNutt2009AntagonismOS,
  title={Antagonism of Secreted PCSK 9 Increases Low Density Lipoprotein Receptor Expression in HepG 2 Cells *},
  author={Markey C. McNutt and Hyock Joo Kwon and Chiyuan Chen and Justin R. Chen and Jay D. Horton and Thomas A. Lagace},
  year={2009}
}
PCSK9 is a secreted protein that degrades low density lipoprotein receptors (LDLRs) in liver by binding to the epidermal growth factor-like repeat A (EGF-A) domain of the LDLR. It is not known whether PCSK9 causes degradation of LDLRswithin the secretory pathway or following secretion and reuptake via endocytosis.Here we show that a mutation in the LDLR EGF-A domain associated with familial hypercholesterolemia, H306Y, results in increased sensitivity to exogenous PCSK9-mediated cellular… CONTINUE READING
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Secreted PCSK9 Causes LDLR Degradation

  • M. Farnier, I. Beucler, +11 authors C. Boileau
  • APRIL 17,
  • 2009

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