Antagonism of CRF Receptors Prevents the Deficit in Brain Reward Function Associated with Precipitated Nicotine Withdrawal in Rats

@article{Bruijnzeel2007AntagonismOC,
  title={Antagonism of CRF Receptors Prevents the Deficit in Brain Reward Function Associated with Precipitated Nicotine Withdrawal in Rats},
  author={Adrie W. Bruijnzeel and George Zislis and Carrie K Wilson and Mark S. Gold},
  journal={Neuropsychopharmacology},
  year={2007},
  volume={32},
  pages={955-963}
}
Nicotine dependence is a chronic mental illness that is characterized by a negative affective state upon tobacco smoking cessation and relapse after periods of abstinence. It has been hypothesized that cessation of nicotine administration results in the activation of brain corticotropin-releasing factor (CRF) systems that leads to the negative affective state of withdrawal. The aim of our experiments was to investigate the role of brain CRF systems in the deficit in brain reward function… CONTINUE READING

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