Antagonism of AMPA receptors produces anxiolytic-like behavior in rodents: Effects of GYKI 52466 and its novel analogues

@article{Kapus2008AntagonismOA,
  title={Antagonism of AMPA receptors produces anxiolytic-like behavior in rodents: Effects of GYKI 52466 and its novel analogues},
  author={G. Kapus and I. Gacs{\'a}lyi and M. Vegh and H. Kompagne and E. Hegedűs and Csilla Leveleki and L. H{\'a}rsing and J. Bark{\'o}czy and A. Bilkei-Gorzo and G. L{\'e}vay},
  journal={Psychopharmacology},
  year={2008},
  volume={198},
  pages={231-241}
}
RationaleAlthough emerging number of data supports the role of glutamate receptors and the potential of their antagonists in anxiety disorders, the involvement of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptors in anxiety is less well characterized.ObjectiveTo evaluate the anxiolytic potential of 2,3-benzodiazepine (2,3BDZ) type AMPA receptor antagonists in various models of anxiety.Materials and methodsWhole-cell currents, hippocampal field potentials… Expand
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