Antagonism of AMPA receptors produces anxiolytic-like behavior in rodents: Effects of GYKI 52466 and its novel analogues

@article{Kapus2008AntagonismOA,
  title={Antagonism of AMPA receptors produces anxiolytic-like behavior in rodents: Effects of GYKI 52466 and its novel analogues},
  author={G. Kapus and I. Gacs{\'a}lyi and M. Vegh and H. Kompagne and E. Hegedűs and Csilla Leveleki and L. H{\'a}rsing and J. Bark{\'o}czy and A. Bilkei-Gorzo and G. L{\'e}vay},
  journal={Psychopharmacology},
  year={2008},
  volume={198},
  pages={231-241}
}
RationaleAlthough emerging number of data supports the role of glutamate receptors and the potential of their antagonists in anxiety disorders, the involvement of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptors in anxiety is less well characterized.ObjectiveTo evaluate the anxiolytic potential of 2,3-benzodiazepine (2,3BDZ) type AMPA receptor antagonists in various models of anxiety.Materials and methodsWhole-cell currents, hippocampal field potentials… Expand
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31 Citations
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31 Citations

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References

SHOWING 1-10 OF 44 REFERENCES
The Putative AMPA Receptor Antagonist, LY326325, Produces Anxiolytic-Like Effects Without Altering Locomotor Activity in Rats
  • 40
  • Highly Influential
Glutamate receptor ligands as anxiolytics.
  • 90
Evidence for an anxiogenic action of AMPA receptor antagonists in the plus-maze test.
  • 26
Some behavioral effects of AMPA/kainate receptor agonist and antagonists.
  • 22
In vitro and in vivo studies in rats with LY293558 suggest AMPA/kainate receptor blockade as a novel potential mechanism for the therapeutic treatment of anxiety disorders
  • 38
5-Hydroxytryptamine-interacting drugs in animal models of anxiety disorders: more than 30 years of research.
  • G. Griebel
  • Biology, Medicine
  • Pharmacology & therapeutics
  • 1995
  • 449
Anxiety-like effects induced by acute fluoxetine, sertraline or m-CPP treatment are reversed by pretreatment with the 5-HT2C receptor antagonist SB-242084 but not the 5-HT1A receptor antagonist WAY-100635.
  • 246
  • PDF
2,3-benzodiazepine AMPA antagonists.
  • 43
Antagonism of non-NMDA receptors in the dorsal periaqueductal grey induces anxiolytic effect in the elevated plus maze
  • 63
  • Highly Influential
Glutamate and anxiety
  • 201
  • Highly Influential
...
1
2
3
4
5
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