Antagonism of AMPA receptors produces anxiolytic-like behavior in rodents: Effects of GYKI 52466 and its novel analogues

@article{Kapus2008AntagonismOA,
  title={Antagonism of AMPA receptors produces anxiolytic-like behavior in rodents: Effects of GYKI 52466 and its novel analogues},
  author={G{\'a}bor L. Kapus and Istv{\'a}n Gacs{\'a}lyi and Miklos G. Vegh and Hajnalka Kompagne and Endre Hegedűs and Csilla Leveleki and L{\'a}szl{\'o} G{\'a}bor H{\'a}rsing and J{\'o}zsef Bark{\'o}czy and Andras Bilkei-Gorzo and Gy{\"o}rgy L{\'e}vay},
  journal={Psychopharmacology},
  year={2008},
  volume={198},
  pages={231-241}
}
Although emerging number of data supports the role of glutamate receptors and the potential of their antagonists in anxiety disorders, the involvement of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptors in anxiety is less well characterized. To evaluate the anxiolytic potential of 2,3-benzodiazepine (2,3BDZ) type AMPA receptor antagonists in various models of anxiety. Whole-cell currents, hippocampal field potentials, elevated plus maze (EPM), meta… CONTINUE READING
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