Antagonism of 5-hydroxytryptamine-evoked excitation in the superficial dorsal horn of the cat spinal cord by methysergide.

@article{Todd1984AntagonismO5,
  title={Antagonism of 5-hydroxytryptamine-evoked excitation in the superficial dorsal horn of the cat spinal cord by methysergide.},
  author={Andrew J Todd and Julian Millar},
  journal={Neuroscience letters},
  year={1984},
  volume={48 2},
  pages={167-70}
}
Ionophoretically applied methysergide was tested on 9 units excited by 5-hydroxytryptamine (5-HT) recorded in the superficial dorsal horn of cat spinal cord. In all cases, methysergide produced a prolonged and repeatable antagonism of the excitatory action of 5-HT, but it had no effect on glutamate-evoked activity or on that caused by adequate stimulation of the receptive field. This result supports the proposal that excitation by 5-HT is a direct synaptic effect, and not a 'non-specific… CONTINUE READING