Antagonism by salvianolic acid B of lipopolysaccharide-induced disseminated intravascular coagulation in rabbits.

@article{Wu2014AntagonismBS,
  title={Antagonism by salvianolic acid B of lipopolysaccharide-induced disseminated intravascular coagulation in rabbits.},
  author={Zheng Wu and Jian-nan Li and Zhi-quan Bai and Xi Lin},
  journal={Clinical and experimental pharmacology & physiology},
  year={2014},
  volume={41 7},
  pages={
          502-8
        }
}
The aim of the present study was to investigate the effects of salvianolic acid B on lipopolysaccharide (LPS)-induced disseminated intravascular coagulation (DIC) in rabbits. Continuous infusion of LPS was used to induce a DIC model in rabbits. Treatment with salvianolic acid B (1, 3 or 6 mg/kg) was started simultaneously with LPS infusion (0.5 mg/kg LPS in 60 mL saline; 10 mL/h over a period of 6 h) through the contralateral marginal ear vein. Activated partial thromboplastin time (APTT… CONTINUE READING

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